This thesis examines the interplay between early-life conditions, major events and health later in life. It consists of two parts. The first part (Chapter 2) investigates longrun effects of adverse conditions very early in life on health and labor market outcomes later in life. The second part (Chapters 3 and 4) examines whether major adverse life events occur more often and have larger effects on health for those individuals who were exposed to adverse conditions early in life, like maternal malnutrition during pregnancy or poverty around the moment of birth. Finally, the chapters provide insight into the health effects of major life events and ease the identification of individuals who are most vulnerable to these shocks. This thesis provides two main conclusions. In utero malnutrition has long-run effects on hospitalization rates and labor market participation. Furthermore, a differential impact of major adverse life events is an underlying part of the widely documented relation between early-life conditions and health later in life.